Foot and Ankle
mohamad taghi peivandi; Farshid Bagheri; Ali Birjandi nezhad; Sara Amel Farzad; Lida Jarahi; Milad Esmail zade; Amin Razi; Reza Habibzadeh shojaie
Abstract
Introduction The use of parathyroid hormone in the management of fracture disorders is poorly documented. Aim of study was evaluation of parathyroid hormone efficacy on :union: of tibia/fibula diaphysis fractures. Materials and methods: It was a hospital-based study who conducted on patient with non-:union: ...
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Introduction The use of parathyroid hormone in the management of fracture disorders is poorly documented. Aim of study was evaluation of parathyroid hormone efficacy on :union: of tibia/fibula diaphysis fractures. Materials and methods: It was a hospital-based study who conducted on patient with non-:union: or delayed-:union: fracture of tibia/fibula. At Shahid Kamyab hospital, patients with inclusion criteria, entered the study after completing the conscious consent form in both case and control groups. CBC, ESR, Ca, P, Mg, ALK-P, Cr, BUN tests were performed as baseline, then in the case group prescribe oral D-Calcium and monthly injection of parathyroid hormone for 3 months at a daily dose of 8 units and in the control group, prescribe oral D-Calcium and the expected treatment method, and those who had a specific risk factor such as digoxin tablets or kidney failure were excluded from the study. After entering the study and receiving the hormone once the month, patients evaluate with radiographic parameter. Results: Of evaluated cases, mean and standard deviation of age in the intervention group was 16.9 ± 37.7 years and in the control group was 13.8 ± 39.1 years (P = 0.73). In terms of gender in the two groups, 24 cases were male and 6 cases were female (P = 1.0). In addition in clinical findings, fracture type (P = 1.0), fracture shape (P = 0.18), fixation method (P = 0.26), radiographical result (P = 0.06) did not have a statistically significant difference between the two groups. Conclusion: We not find any positive effect of this hormon on fracture status, as clinical or para clinical evaluation.
Amin Razi; Mohammad taghi Peivandi; Ali Birjandinejad; Sara Amel Farzad
Abstract
Abstract
Background: Nonunion is a serious complication following long-bone fracture that is known as a therapeutic challenge for surgeons and is associated with significant morbidity. It has been shown that osteogenesis stimulating factors combined with optimization of the mechanical environment could ...
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Abstract
Background: Nonunion is a serious complication following long-bone fracture that is known as a therapeutic challenge for surgeons and is associated with significant morbidity. It has been shown that osteogenesis stimulating factors combined with optimization of the mechanical environment could facilitate and accelerate nonunion healing. In this study, we aimed to treat nonunion using autologous bone marrow-derived mononuclear cell (BMDMC) aspirate as a source of osteoprogenitor cells combined with internal fixation.
Methods: From November 2010 to May 2013, 19 cases of nonunion were treated with bone marrow-derived mononuclear cell (BMDMC) grafting, that included 15 males and 4 females with an average age of 37.8 years (range, 18-81 years). The time from injury to therapy was 7 to 28 months, with an average of 13.4 months. At first, decortications were performed around the nonunion site to prepare a suitable bed for bone marrow grafting. Then, 2 ml of bone marrow concentrated cells was applied to the nonunion site in a mixture with partially demineralized cortical cancellous allograft chips. The healing rate in each patient was clinically and radiologically evaluated every 4 weeks.
Results: Bone union was obtained in 18 of the 19 patients during 1.06 to 6 months with an average time of 3.5 months. No complications during anesthesia nor any infection, hematoma or chronic pain at the nonunion site were observed in any patient.
Conclusion: Transplantation of autologous BMDMC aspirate is a reasonable, effective and easy treatment option for tibial and femoral nonunion after internal fixation.
Trial registration: This study has been registrated in ClinicalTrials.gov (https://clinicaltrials.gov).
TRN:NCT01788059
amin razi; Mohammad-Taghi Peivandi; Ali Birjandinejad; Ali Parsa; Sara Amel Farzad; Maryam Hosseini Hasanabady
Abstract
Orthopaedics tissues, such as bone, cartilage, and tendon, involve cells that are difficult to culture and grow in vitro for reconstruction of damaged tissues. A small number of cells called stem cells have the ability to self-renew and differentiate into connective tissue lineages, involving bone, cartilage, ...
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Orthopaedics tissues, such as bone, cartilage, and tendon, involve cells that are difficult to culture and grow in vitro for reconstruction of damaged tissues. A small number of cells called stem cells have the ability to self-renew and differentiate into connective tissue lineages, involving bone, cartilage, tendon and ligaments. Recent development in stem cell research has led to an exciting effort in applying stem cells for orthopaedics tissue regeneration. This review summarizes recent findings regarding the potential clinical use of Mesenchymal Stem Cells (MSCs) in Non:union:s, Osteogenesis imperfect, Human Cartilage defects, Osteoarthritis and Rheumatoid arthritis to provide a better understanding of the issue engineering with stem cell research, as well as the potential therapeutic purpose of these cells in orthopedic surgery.
Mohammad Taghi Peivandi; Amir Reza Kachooei; Eghbal Sadri Mahvelati; Seyyedeh Zahra Mostafavian; Mohammad Hosein Ebrahimzadeh; Amin Razi
Abstract
Background: Distal radius fracture is among the most common fractures of the long bones that are seen in all age groups. Presence of different treatment protocols explains the challenge and controversy in treatment. Methods: In a clinical trial study, on 100 patients with stable extra articular distal ...
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Background: Distal radius fracture is among the most common fractures of the long bones that are seen in all age groups. Presence of different treatment protocols explains the challenge and controversy in treatment. Methods: In a clinical trial study, on 100 patients with stable extra articular distal radius fractures, 50 cases were randomly treated with short and 50 with long arm casts in a one year period in three training hospitals in Mashhad-Iran. All the long casts were changed to short casts in the forth week and all the casts discontinued in the sixth week and the patients assessed for the elbow range of motion , forearm supination-pronation, :::union:::, mal:::union:::, the patient satisfaction, and distal radioulnar joint stability in the 6th and 18th weeks after treatment. Results: The severity of fractures in both groups was similar. We didn’t find any case of non:::union:::, unacceptable mal:::union:::, regional pain syndrome, carpal tunnel syndrome or compartment syndrome. All the patients with short arm cast were satisfied in contrast to the other group. Range of motion had been better saved in short arm cast and in younger patients. Conclusion: This study shows that the effectiveness of short arm cast is the same as long arm cast the complications are fewer than long arm cast, and the patient's satisfaction is better in short arm cast. So, we suggest closed reduction and short arm cast for the treatment of stable extraarticular A2 type of OTA distal radius fractures.
